Rapidly and slowly activating components of delayed rectifier K + current in guinea‐pig sino‐atrial node pacemaker cells
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چکیده
منابع مشابه
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cells.
We have investigated the physiological role of the "rapidly activating" delayed rectifier K+ current (IKr) in pacemaker activity in isolated sinoatrial node (SAN) myocytes and the expression of mouse ether-a-go-go (mERG) genes in the adult mouse SAN. In isolated, voltage-clamped SAN cells, outward currents evoked by depolarizing steps (greater than -40 mV) were strongly inhibited by the class I...
متن کاملA rapidly-activating delayed rectifier K current, IKr, regulates pacemaker activity in adult mouse sinoatrial node cells Short title: IKr regulates mouse cardiac pacemaker activity
Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, 3330 Hospital Drive, N.W., Calgary, Alberta, Canada T2N 4N1 *Laboratoire de Genomique Fonctionnelle CNRS UPR 2580 and Institut de Genetique Humaine, CNRS UPR 1142 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France Department of Internal Medicine, Karl-Franzens-University Hospital, Auenbruggerplatz 1...
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Class III antiarrhythmic drugs show promise as effective treatments for the suppression of potentially lethal cardiac arrhythmias. Dofetilide (UK-68,798), is a potent class III antiarrhythmic agent that is presently under clinical investigation. The objective of this study was to determine whether [3H]dofetilide could be used as a specific radioligand for the rapidly activating delayed rectifie...
متن کاملSevoflurane inhibition of the slowly activating delayed rectifier K+ current in guinea pig ventricular cells.
Single ventricular cells were enzymatically isolated from guinea pig hearts and the effects of sevoflurane on the delayed rectifier K(+) current were investigated by the patch clamp method. The rapidly (I(Kr)) and slowly activating delayed rectifier K(+) current (I(Ks)) were isolated using chromanol 293B, a selective blocker for I(Ks) or E4031 (N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperid...
متن کاملAntiarrhythmic Agent Specific Block of Rapidly Activating Delayed Rectifier K' Current by Dofetilide
Class III antiarrhythmic agents act by selective prolongation of cardiac action potential duration (APD). Methanesulfonanilide class III agents (e.g., E-4031 and dofetilide) are extremely potent and lengthen action potentials in a "reverse" rate-dependent manner; i.e., effects are greater at low compared with high rates of stimulation. By using the whole-cell current-clamp technique in isolated...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2002
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2001.016741